First off, some plugins that I'm using.
Color-themes is great and allows me a fair bit of selection when it comes to colorizing my editor. ( )
Also, I'm using tabbar.el to give me tab functionality I'd be lost without my tabs. ( )
As for commands, I'll sort them by category.
C-x C-f Open a file. C-x C-s Save the file in the current buffer. C-x s Save all buffers.
C-_ Undo (that's an underscore). M-del Delete last word. C-x del Delete to beginning of sentence. C-t Transpose two letters M-t Transpose two words M-d Kill a word. M-k Kill to end of sentence. M-z char Kill up to next occurrence of char.
C-s Incremental search forward. C-s C-s Cancel forward search. C-r Incremental search backward.Buffers
C-x k Kill a specific buffer by name (RET by default kills the current buffer. C-x C-q Flag a buffer as read-only. C-x C-b List buffers